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药学学科硕士研究生导师刘彬简介
2022-02-27 10:07  

刘彬 | PhD


姓名:刘彬 性别:男

 

职称:教授

职务:江苏海洋大学药hjcvg黄金城会员登录副院长、硕士生导师

学历学位:博士研究生

本人简介:

【教育经历】

2006hjc黄金城登录地址6月毕业于华中科技大学同济医hjcvg黄金城会员登录,获医学学士学位

2012hjc黄金城登录地址6月毕业于上海交通大学医hjcvg黄金城会员登录,获理学博士学位

2014hjc黄金城登录地址6月在中国科hjcvg黄金城会员登录上海药物研究所完成博士后研究

【学术成绩】

刘彬博士为江苏特聘教授,江苏海洋大学教授,江苏海洋大学药hjcvg黄金城会员登录副院长,江苏省海洋药物活性分子筛选重点实验室副主任,长期专注于研究蛋白质稳态,特别是蛋白质泛素化降解在肿瘤、代谢性疾病和靶向蛋白质降解小分子药物(分子胶水)中的分子机制和生物功能。近五hjc黄金城登录地址来,刘彬博士主持和共同主持国家自然科学基金项目4项,省部级项目3项, 在CellNature communications, Journal of Clinic InvestigationProc Natl Acad Sci U S ACell Death & DifferentiationNucleic acids research DiabetesCancer letters以及Cell Death & Disease等国际主流学术期刊上发表中科院一区SCI论文20余篇,他引1100余次。

 

   主要研究方向介绍:

  1. 长期从蛋白质翻译后修饰,特别是蛋白质泛素化降解相关调控酶(泛素E3连接酶,去泛素化酶等)在肿瘤和重大代谢性疾病中的机制和功能。

  2. 采取另辟蹊径的高通量药物筛选方式,利用高内涵化合物库,系统性筛选靶向蛋白质降解的小分子药物。

  3. 通过高通量定量基因/蛋白质组学技术结合结构生物学以及生物信息学/分子生物学/细胞生物学/实验动物学等技术,系统性阐明靶向蛋白质降解小分子的药理机制。

     

主要研究项目:

  1. 2021-102023-10,连云港花果山英才,30万,主持,在研。

  2. 2020-8 2023-08,  江苏特聘教授, 100万,主持,在研。

  3. 2019-1 2022-12,靶向泛E3连接酶的抗肿瘤免疫调节剂新底物和机理研究,81872888,国家自然科学基金面上项目,57万,共同主持,在研。

  4. 2018-1 2021-12FBXO2识别并调控糖基化 c-Met蛋白在肿瘤发生与转移中的作用及其分子机制,81773018,国家自然科学基金面上项目,55万,主持,结题。

  5. 2017-1 2020-12,模式微生物蛋白酰基化新修饰与代谢通路动态调控关系的探究,31670066, 国家自然科学基金面上项目,62万、共同主持,结题。

  6. 2015-1 2017-12 FBXO6与糖基化 Ero1L相互作用在内质网应激中的分子机制及其生物学意义,31401185,国家自然科学基金青hjc黄金城登录地址项目,26万,主持,结题。

  7. 2013-12014-12, SIRT1相互作用蛋白质网络的组学研究, 2013M541566, 国家博士后基金面上项目,5, 主持,结题。

     

代表性成果:

5hjc黄金城登录地址内发表的5篇代表性论著

1. Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B and Tan M. Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ. 2022;29:1-13. (SCI一区,影响因子15.828,共同通讯作者)

2. Liu B, Xiang L, Ji J, Liu W, Chen Y, Xia M, Liu Y, Liu W, Zhu P, Jin Y, Han Y, Lu J, Li X, Zheng M and Lu Y. Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2. J Clin Invest. 2021;131. (SCI一区,影响因子14.808,第一作者)

3. Ji M, Zhao Z, Li Y, Xu P, Shi J, Li Z, Wang K, Huang X and Liu B. FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer. Cell Death Dis. 2021;12:317. (SCI一区,影响因子8.469,最后通讯作者)

4. Liu B, Zhang Z, Hu Y, Lu Y, Li D, Liu J, Liao S, Hu M, Wang Y, Zhang D, Chen Y, Qian Q, Lv X, Wu D, Tan M, Hu C, Xiong X and Li X. Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14. Proc Natl Acad Sci U S A. 2019;116:21732-21738. (SCI一区,影响因子11.205,第一作者)

5. Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y, Li X and Tan M. Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. Nat Commun. 2018;9:4770. (SCI一区,影响因子14.919,第一作者)

5hjc黄金城登录地址内发表的其他论著

1. Tong Y, Li J, Peng M, Qian Q, Shi W, Chen Z and Liu B. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors. Biochem Biophys Res Commun. 2022;594:146-152. (SCI三区,影响因子3.575,最后通讯作者)

2. Li G, Shi W, Xu Y, Li K, Chen Z, Lv M, Lv J, Qiu T, Qian Q, Ji J, Liu W, Liu B and Zhao Y. The USP18-FBXO6 axis maintains the malignancy of ovarian cancer. Biochem Biophys Res Commun. 2022;593:101-107. (SCI三区,影响因子3.575,共同通讯作者)

3. Ji J, Xie M, Qian Q, Xu Y, Shi W, Chen Z, Ren D, Liu W, He X, Lv M, Ma J, Liu W, Li A and Liu B. SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer. Biochem Biophys Res Commun. 2022;587:139-145. (SCI三区,影响因子3.575,最后通讯作者)

4. Zhao M, Hu M, Chen Y, Liu H, Chen Y, Liu B and Fang B. Cereblon modulator CC-885 induces CRBN-dependent ubiquitination and degradation of CDK4 in multiple myeloma. Biochem Biophys Res Commun. 2021;549:150-156. (SCI三区,影响因子3.575,共同通讯作者)

5. Wan J, Liu S, Sun W, Yu H, Tang W, Liu W, Ji J and Liu B. Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression. Cancer Cell Int. 2021;21:122. (SCI三区,影响因子5.722,最后通讯作者)

6. Shi M, Dai WQ, Jia RR, Zhang QH, Wei J, Wang YG, Xiang SH, Liu B and Xu L. APC(CDC20)-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma. Cancer Lett. 2021;496:144-155. (SCI一区,影响因子8.679,共同通讯作者)

7. Ji M, Zhao Z, Li Y, Xu P, Shi J, Li Z, Wang K, Huang X, Ji J, Liu W and Liu B. FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer. Cell Death Dis. 2021;12:758. (SCI一区,影响因子8.469,最后通讯作者)

8. Xu JY, Zhang C, Wang X, Zhai L, Ma Y, Mao Y, Qian K, Sun C, Liu Z, Jiang S, Wang M, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang X, Zhao L, Chang Y, Jia J, Wang X, Zhang Y, Wang Y, Yang Y, Wu Z, Yang L, Liu B, Zhao T, Ren S, Sun A, Zhao Y, Ying W, Wang F, Wang G, Zhang Y, Cheng S, Qin J, Qian X, Wang Y, Li J, He F, Xiao T and Tan M. Integrative Proteomic Characterization of Human Lung Adenocarcinoma. Cell. 2020;182:245-261 e17. (SCI一区,影响因子41.582,参与作者)

9. Wang G, Chen S, Xie Z, Shen S, Xu W, Chen W, Li X, Wu Y, Li L, Liu B, Ding X, Qin A and Fan S. TGFbeta attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination. Ann Rheum Dis. 2020;79:1111-1120. (SCI一区,影响因子19.103,参与作者)

10. Wan J, Wu X, Chen H, Xia X, Song X, Chen S, Lu X, Jin J, Su Q, Cai D, Liu B and Li B. Aging-induced aberrant RAGE/PPARalpha axis promotes hepatic steatosis via dysfunctional mitochondrial beta oxidation. Aging Cell. 2020;19:e13238. (SCI一区,影响因子9.304,参与作者)

11. Wan J, Shan Y, Song X, Chen S, Lu X, Jin J, Su Q, Liu B, Sun W and Li B. Adipocyte-derived Periostin mediates glucocorticoid-induced hepatosteatosis in mice. Mol Metab. 2020;31:24-35. (SCI二区,影响因子7.422,参与作者)

12. Lu Y, Wang E, Chen Y, Zhou B, Zhao J, Xiang L, Qian Y, Jiang J, Zhao L, Xiong X, Lu Z, Wu D, Liu B, Yan J, Zhang R, Zhang H, Hu C and Li X. Obesity-induced excess of 17-hydroxyprogesterone promotes hyperglycemia through activation of glucocorticoid receptor. J Clin Invest. 2020;130:3791-3804. (SCI一区,影响因子14.808,参与作者)

13. Li L, Xue W, Shen Z, Liu J, Hu M, Cheng Z, Wang Y, Chen Y, Chang H, Liu Y, Liu B and Zhao J. A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer. Mol Ther Oncolytics. 2020;18:215-225. (SCI二区,影响因子7.200,共同通讯作者)

14. Jia X, Pan L, Zhu M, Hu H, Zhai L, Liu J, Hu M, Liu B and Tan M. pSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate. J Proteomics. 2020;210:103545. (SCI二区,影响因子4.044,共同通讯作者)

15. Hao BB, Li XJ, Jia XL, Wang YX, Zhai LH, Li DZ, Liu J, Zhang D, Chen YL, Xu YH, Lee SK, Xu GF, Chen XH, Dang YJ, Liu B and Tan MJ. The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L. Acta Pharmacol Sin. 2020;41:1246-1254. (SCI一区,影响因子6.150,共同通讯作者)

16. Lan Z, Lee MY, Chun E, Liu B and Liu W. Overview of Biochemical Assays in Lipidic Cubic Phase. Trends Biochem Sci. 2019;44:295-299. (SCI一区,影响因子13.807,参与作者)

17. Du SC, Zhu L, Wang YX, Liu J, Zhang D, Chen YL, Peng Q, Liu W and Liu B. SENP1-mediated deSUMOylation of USP28 regulated HIF-1alpha accumulation and activation during hypoxia response. Cancer Cell Int. 2019;19:4. (SCI三区,影响因子5.722,最后通讯作者)

18. Zhao J, Xiong X, Li Y, Liu X, Wang T, Zhang H, Jiao Y, Jiang J, Zhang H, Tang Q, Gao X, Li X, Lu Y, Liu B, Hu C and Li X. Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A. Diabetes. 2018;67:818-830. (SCI一区,影响因子9.461,共同通讯作者)

19. Xu HZ, Wang ZQ, Shan HZ, Zhou L, Yang L, Lei H, Liu B and Wu YL. Overexpression of Fbxo6 inactivates spindle checkpoint by interacting with Mad2 and BubR1. Cell Cycle. 2018;17:2779-2789. (SCI三区,影响因子4.534,共同通讯作者)

20. Jiao Y, Zhao J, Zhang Z, Li M, Yu X, Yang Y, Liu J, Liao S, Li D, Wang Y, Zhang D, Chen Y, Shi G, Liu B, Lu Y and Li X. SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c. Diabetes. 2018;67:2227-2238. (SCI一区,影响因子9.461,共同通讯作者)

21. Liu B, Lu H, Li D, Xiong X, Gao L, Wu Z and Lu Y. Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes. 2017;66:689-698. (SCI一区,影响因子9.461,第一作者)

5hjc黄金城登录地址以外的代表性论著

1. Wu L, Lu Y, Jiao Y, Liu B, Li S, Li Y, Xing F, Chen D, Liu X, Zhao J, Xiong X, Gu Y, Lu J, Chen X and Li X. Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring. Cell Metab. 2016;23:735-43. (SCI一区,影响因子27.287,参与作者)

2. Chen ZW, Liu B, Tang NW, Xu YH, Ye XY, Li ZM, Niu XM, Shen SP, Lu S and Xu L. FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res. 2014;42:11560-9. (SCI一区,影响因子16.971,共同第一作者)

3. Qiu Z, Liu M, Chen Z, Shao Y, Pan H, Wei G, Yu C, Zhang L, Li X, Wang P, Fan HY, Du B, Liu B, Liu M and Li D. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res. 2013;41:e120. (SCI一区,影响因子16.971,参与作者)

4. Liu B, Zheng Y, Wang TD, Xu HZ, Xia L, Zhang J, Wu YL, Chen GQ and Wang LS. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. J Proteome Res. 2012;11:1773-81. (SCI二区,影响因子4.466,第一作者)

 

联系方式:

电子邮箱:liubin@jou.edu.cn

量课题组之物力,助学生之蜕变,接收有一定实验基础和文献阅读能力的调剂生。

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