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药学学科硕士研究生导师王晓斌简介
2021-10-21 07:44  

王晓斌 | PhD

 姓名:王晓斌 性别:男

 职称:讲师

 职务:硕士生导师

 学历学位:博士研究生

 本人简介:

 2014hjc黄金城登录地址7月毕业于铜仁hjcvg黄金城会员登录生物科学与化学工程系化学专业,获理学学士学位

 2017hjc黄金城登录地址6月毕业于贵州大学精细化工研究开发中心农药学专业,获理学硕士学位

 2021hjc黄金城登录地址6月毕业于南京农业大学理hjcvg黄金城会员登录天然产物化学专业,获理学博士学位

 2021hjc黄金城登录地址7月至今,在江苏海洋大学药hjcvg黄金城会员登录工作

王晓斌,主要从事天然产物仿生药物的创制、靶向功能蛋白的药物创制两方面的研究工作。主持江苏海洋大学人才引进科研基金项目1项,在研项目经费15万元。以第一作者在Journal of Agricultural and Food ChemistryEuropean Journal of Medicinal ChemistryChinese Chemical LettersBioorganic & Medicinal Chemistry等期刊上发表SCI收录论文16篇,申请发明专利5项,授权专利2项。

擅长教学:

《天然产物化学》

主要研究方向介绍:

天然产物仿生药物的创制

靶向功能蛋白的药物创制

主要研究项目:

1、课题名称:喹唑啉酮酰肼类分子的修饰、抑菌活性及3D-QSAR研究;课题编号:KYCX19_0602;课题来源:江苏省研究生科研创新计划。

2、课题名称:基于优势先导喹唑啉酮酰肼的仿生生物碱及其抑菌构效关系;课题编号:KQ21031;课题来源:江苏海洋大学人才引进项目。

代表性成果:

【期刊论文】

  1. Wang Xiaobin, Wang Mengqi, Han Ling, Jin Fei, Jiao Jian, Chen Min, Yang Chunlong, Xue Wei. Novel pyrazole-4-acetohydrazide derivatives potentially targeting fungal succinate dehydrogenase: Design, synthesis, three-dimensional quantitative structure-activity relationship, and molecular docking. Journal of Agricultural and Food Chemistry, 2021, 69, 95579570. (SCI, 第一作者, IF = 5.279).

  2. Wang Xiaobin, Chai Jianqi, Kong Xiangyi, Jin Fei, Chen Min, Yang Chunlong, Xue Wei. Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment. Bioorganic & Medicinal Chemistry, 2021, 45, 116330. (SCI, 第一作者, IF = 3.641).

  3. Wang Xiaobin, Wang An, Qiu Lingling, Chen Min, Lu Aimin, Li Guohua, Yang Chunlong, Xue Wei. Expedient discovery for novel antifungal leads targeting succinate dehydrogenase: Pyrazole-4-formylhydrazide derivatives bearing a diphenyl ether fragment. Journal of Agricultural and Food Chemistry, 2020, 68, 1442614437. (SCI, 第一作者, IF = 5.279).

  4. Wang Xiaobin, Fu Xincan, Chen Min, Wang An, Yan Jinghua, Mei Yudong, Wang Mengqi, Yang Chunlong. Novel 1,3,5-thiadiazine-2-thione derivatives containing a hydrazide moiety: Design, synthesis and bioactive evaluation against phytopathogenic fungi in vitro and in vivo. Chinese Chemical Letters, 2019, 30, 14191422. (SCI, 第一作者, IF = 4.632).

  5. Wang Xiaobin, Hu Haoran, Zhao Xu, Chen Min, Zhang Tingting, Geng Chunwen, Mei Yudong, Lu Aimin, Yang Chunlong. Novel quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety as potential bactericides and fungicides: Design, synthesis, characterization and 3D-QSAR analysis. Journal of Saudi Chemical Society, 2019, 23, 11441156. (SCI, 第一作者, IF = 3.584).

  6. Wang Xiaobin, Fu Xincan, Yan Jinghua, Wang An, Wang Mengqi, Chen Min, Yang Chunlong, Song Yimin. Design and synthesis of novel 2-(6-thioxo-1,3,5-thiadiazinan-3-yl)-N'-phenylaceto hydrazide derivatives as potential fungicides. Molecular Diversity, 2019, 23, 573583. (SCI, 第一作者, IF = 2.060).

  7. Wang Jiequan, Wang Xiaobin, Wang Yang, Tang Wenjian, Shi Jingbo, Liu Xinhua. Novel curcumin analogue hybrids: Synthesis and anticancer activity. European Journal of Medicinal Chemistry, 2018, 156, 493509. (SCI, 并列一作, IF = 4.833).

  8. Wang Xiaobin, Ren Zhengjiao, Wang Mengqi, Chen Min, Lu Aimin, Si Weijie, Yang Chunlong. Design and synthesis of novel 3-(thiophen-2-yl)-1,5- dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone moiety as potential fungicides. Chemistry Central Journal, 2018, 12, 83. (SCI, 第一作者, IF = 2.094).

  9. Wang Xiaobin, Yan Jinghua, Wang Mengqi, Liu Menghan, Zhang Juping, Chen Lijuan, Xue Wei. Synthesis and three-dimensional quantitative structure-activity relationship study of quinazoline derivatives containing 1,3,4-oxadiazole scaffold as efficient inhibitors against Xanthomonas axonopodis pv. citri. Molecular Diversity, 2018, 22, 791802. (SCI, 第一作者, IF = 2.032).

  10. Chen Lijuan, Wang Xiaobin, Tang Xu, Xia Rongjiao, Guo Tao, Zhang Cheng, Li Xiangyang, Xue Wei. Design, synthesis, antiviral bioactivities and interaction mechanisms of penta1,4diene3one oxime ether derivatives containing a quinazolin4(3H)one scaffold. BMC Chemistry, 2019, 13, 34. (SCI, 并列一作, IF = 2.493).

  11. Zhong Xinmin, Wang Xiaobin, Chen Lijuan, Ruan Xianghui, Li Qin, Zhang Juping, Chen Zhuo, Xue Wei. Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold. Chemistry Central Journal, 2017, 11, 106. (SCI, 并列一作, IF = 2.284).

  12. Wang Xiaobin, Ren Zhengjiao, Mei Yudong, Liu Menghan, Chen Min, Si Weijie, Yang Chunlong, Song Yimin. Design, synthesis and antifungal activity of 3-(thiophen-2-yl)-1,5- dihydro-2H-pyrrol-2-one derivatives bearing a carbonic ester group. Journal of Heterocyclic Chemistry, 2019, 56, 165171. (SCI, 第一作者, IF = 1.484).

  13. Wang Xiaobin, Wang Mengqi, Yan Jinghua, Chen Min, Wang An, Mei Yudong, Si Weijie, Yang Chunlong. Design, synthesis and 3D-QSAR of new quinazolin-4(3H)-one derivatives containing a hydrazide moiety as potential fungicides. ChemistrySelect, 2018, 3, 1066310669. (SCI, 第一作者, IF = 1.716).

  14. Wang Xiaobin, Chen Meihang, Li Qin, Zhang Juping, Ruan Xianghui, Xie Yan, Xue Wei. Synthesis and antiviral activities of novel 1,4-pentadien-3-one oxime derivatives bearing pyridine moiety. Chemical Papers, 2017, 71, 12251233. (SCI, 第一作者, IF = 1.198).

  15. Wang Xiaobin, Zhong Xinmin, Zhu Xuesong, Wang Hua, Li Qin, Zhang Juping, Ruan Xianghui, Xue Wei. Synthesis and antibacterial activity of oxime ester derivatives containing 1,2,4-triazole or 1,3,4-oxadiazole moiety. Chemical Papers, 2017, 71, 19531960. (SCI, 第一作者, IF = 1.198).

  16. Chen Meihang, Wang Xiaobin, Tang Bangcheng, Zhang Xu. Synthesis and antibacterial evaluation of novel Schiff base derivatives containing 4(3H)-quinazolinone moiety. Chemical Papers, 2016, 70, 15211528. (SCI, 并列一作, IF = 1.258).

  17. 夏丽娟, 王晓斌, 谢艳, 王晓燕, 肖维, 钟新敏, 黄民国, 薛伟. 含杂环1,4-戊二烯-3-酮肟酯类化合物的合成及生物活性. 应用化学, 2017, 34, 316323. (中文核心, 并列一作).

  18. 王晓斌, 夏丽娟, 谢艳, 王晓燕, 肖维, 钟新敏, 黄民国, 薛伟. 含肟酯结构的姜黄素衍生物的合成及抗病毒活性. 农药, 2016, 55, 641646. (中文核心, 第一作者).

【授权专利】

1、薛伟, 王晓斌, 李琴, 陈丽娟, 谢艳, 王一会, 吴小琼, 张菊平, 阮祥辉, 羊春燕, 何桂芳. 一种含4(3H)-喹唑啉酮的1,4-戊二烯-3-酮肟醚类衍生物及其制备方法. 国家发明专利,专利号: ZL201611119587.3, 授权日: 2019hjc黄金城登录地址0809.

2、薛伟, 王晓斌, 刘高峰, 陈丽娟, 怀自友, 王一会, 钱坤, 李琴, 张菊平, 阮祥辉. 一种含香豆素的1,4-戊二烯-3-酮类衍生物及其制备方法和应用. 国家发明专利, 专利号: ZL201710134400.5, 授权日: 2020hjc黄金城登录地址0218.

联系方式:

电子邮箱:bin19910316@sina.com; XB_Wang@jou.edu.cn

 

 

 


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